Combinatorial compound and peptide libraries are valuable tools in molecular biology and medicine
Jung, G.
Institute of Organic Chemistry, University of Tübingen, Auf der Morgenstelle 18,
D-72076 Tübingen, Germany
With combinatorial chemistry millions of organic compounds can be produced simultaneously and quickly. These compound libraries are a cost-effective resource for the pharmaceutical industry in their search for biologically active lead structures. Simultaneous parallel syntheses of single peptides and peptide libraries solve the problem of the worldwide increasing demand for peptides. The automated methods used for peptide library production contributed to a forward-looking technology in organic chemistry on solid supports.
Fast and efficient analytical techniques are essential for various synthetic approaches and technologies, characterizing the complicated product mixtures and detecting by-products. Mass spectrometry and screening assays in solution and on microstructured surfaces are discussed on selected examples. An indispensible source of information for every researcher in this rapidly developing field, which spans biochemistry, biotechnology, pharmaceutical, medicinal, and organic chemistry is found in the following references. Present trends are: simultaneous parallel synthesis of single organic compounds, no tagging, development of solid supports, novel anchors and automation.
The combinatorial approaches are explained in detail for two typical examples: 1. Design, synthesis and screening of a novel gyrase inhibitor based on a synthetic alkaloid library. 2. Elucidation of the immunological code and screening for peptide ligands triggering the T cell responses in autoimmune diseases.
[1] Jung, G. (ed.) (1996) Combinatorial peptide and nonpeptide libraries, VCH, Weinberg
| LOCATION |
DATE |
TIME |
| Lecture Hall II |
Sunday, April 5 |
05:10 pm |