The electrophysiological signal conductance in the extracellular cartilage matrix as an experimental model of cellular mechanisms
Regling, G.
former Department of Orthopaedics, Humboldt University Berlin, Kollwitzstraße 73,
D-10435 Berlin, Germany
Cartilage tissue consists to about 90 per cent of extracellular matrix with regularly arranged native biopolymers. Therefore cartilage tissue is interestingly not only for orthopaedical studies (pathophysiology of osteoarthrosis, of pseudarthrosis, of aging), but rather likewise for the scientific analysis of functional physical effects at native biopolymers. The author pursued this conception over 20 years. The collagen fibril of the cartilage matrix has obviously a similar signal conducting function as well as the cytoskeleton of the cell, and effects of a high frequency coherence (H. Fröhlich) are possibly involved at both structures as a decisive biophysical mechanism. A shorter overview is given at the experimental development of the hypothesis that the collagen fibril of the extracellular matrix of connective tissue mediates a signal conduction. After that an experiment is reported with an oscillating circuit at a native bovine rip cartilage sample, which allows the conclusion, perhaps for the first time, on the existence of a MHz-resonancy phenomenon having a characteristic biophysical property of the examined cartilage sample. This resonancy lies in the range of 1.08 MHz. The possible meaning of such results for the investigation of cellular oscillators and signal tranductions will be discussed.
Regling, G., Rückmann, I. (1989) Bioelectrochemistry & Bioenergetics, 22, 241-254.
Regling, G., Rückmann, I. (1993) An integrative concept for an electrophysiological signal system in the connective tissue matrix. The native collagen fibril as biosensor and signal-conduction structure between nerve and cell as well as in the intercellular matrix, and a discussion of the underlying mechanisms. In: Regling, G. (Ed.), Wolff s Law and Connective Tissue Regulation, Walter de Gruyter, Berlin, New York, 171-192.
Kappert, U., Volkmann, T. (1997) Thesis, Humboldt University Berlin, Faculty of Medicine
Hameroff, S.R.: Coherence in the cytoskeleton: Implications for biological information processing, In: Fröhlich, H. (ed.) Biological coherence and response to external stimuli. Springer Berlin, Heidelberg, New York, 2988, 242-265.
| LOCATION |
DATE |
TIME |
| Lecture Hall II |
Thursday, April 9 |
10:05 am |